Cover Image

A new biopotentially active isoflavone glycoside from the stem of Ficus arnottiana Miq.

Shweta Singh, R.N. Yadava, Ritu Yadav, Vijayshri Surywanshi

Abstract


A new bioactive isoflavone glycoside with a molecular formula C34H42O20, melting point 261°C-263°C and [M]+ 770 was isolated from the methanol soluble fraction of 90% methanolic extract of the stem of Ficus arnottiana Miq. The compound was illustrated as a new bioactive isoflavone glycoside 5,6,5ˈ-trihydroxy-8,3ˈ-dimethoxy-isoflavone 5ˈ-O-α-L-rhamnopyranosyl (1→3) O-α-L xylopyranosyl 5-O-β-D-glucopyranoside were characterized with the help of various chemical reactions, Fourier transforms infrared spectroscopy (FT-IR), Nuclear magnetic resonance spectroscopy (1HNMR), Mass spectrometry (LC-MS) and chemical degradations. Isolated compounds were also used for the antimicrobial activity of micro-organisms worked successfully tested against all strains: Escherichia coli, Bacillus cereus, and Staphylococcus aureus, while the least activity by Pseudomonas aeruginosa.

Full Text:

PDF

References


R.N. Chopra, S.L. Nayar, I.C. Chopra, Glossary of Indian Medicinal Plants NAG Publication, New Delhi, 2002.

B. Kirtikar, B.D. Basu, Indian Medicinal Plant, 3rd Edition, Dehradun, International Book Distributors, 2005, 2312.

R. Singh, A. Ali, Y.J. Kumar, A. Semwal, Development of quality control parameters for the standardization of bark of Ficus arnottiana Miq.(M), Journal of acute disease, 2013, 2(3),

-22.

P.M. Dewick, Medicinal Natural Products: A Biosynthetic Approach, 3 Edition, Chichester, Wiley, 2009, 450-456.

A. Hofman, M.A. Beydoun, Dietary intake of antioxidants and risk of Alzheimer’s disease, Journal of the American Medical Association, 2015, 287, 3223-3229.

M. Ebrahimzadeh, F. Bahramian, Antioxidant activity of Crataegus pentaegyna subsp. elburensis fruits extracts used in traditional medicine in Iran, Pakistan, Journal Biol Sci., 2009, 12, 413- 419.

AOAC, Official methods of analysis of AOAC International, Virginia, USA, 2014, 16, 111-114.

A. Babu, D. Anand, P. Saravanan, Phytochemical Analysis of Ficus arnottiana (Miq.) Miq. Leaf Extract Using GC-MS Analysis, International Journal of Pharmacognosy and Phytochemical Research, 2017, 9(6), 775-779.

H. Budzikiewicz, C. Djerassi, D.H. Williams, Structure elucidation of natural products by mass spectrometry, San Francisco, Holden-Day, 2010, 13-16.

A.J. Alonso-Castro, J.J. Maldonado-Miranda, A. Zárate-Martínez, Medicinal plants used in the Huasteca Potosina, Mexico Journal Ethnopharmacol., 2012, 1, 292–298.

M.D. Rahman, Rahman, L. Ahmad, Exploring the plant-derived bioactive substances as an antidiabetic agent: an extensive review, Biomedicine & Pharmacotherapy, 2022, 152-158.

P.M. Mazumder, M. Farswan, V. Parcha, V. Singh, Hypoglycemic and antioxidant activity of an isolated compound from Ficusarnottiana bark, Journal Pharmacology, 2008, 509-519.

J. Parekh, C. Sumitra, Antibacterial and phytochemical studies on twelve species of Indian medicinal plants, Afr. Journal Biomed. Res., 2007, 10, 175–181.

R. Gyawali, S.A. Hayek, S.A. Ibrahim, Plants extracts as antimicrobials in food products: types. In: Handbook of Natural Antimicrobials for Food Safety and Quality, Ed., Elsevier, 2015, 31–47.

R.N. Yadava, V. Surywanshi, Antioxidant Activity of the Allelochemicals Isolated from Plant Xanthium strumarium Linn., Journal of Biologically Active Products from Nature, 2017, 7, 62-71.

N. Chaudhary, S.S. Husain, A. Mohammed, Phytochemical investigation of the stem bark of Ficus hispida, Journal of Scientific & Innovative Research, 2014, 4, 409-413.

F.R. Cockerill, M.A. Wikler, J. Alder, Performance Standards for Antimicrobial Disk Susceptibility Tests, Approved Standards, 11th Edition, Wayne, PA: Clinical and Laboratory Standards Institute, 2012, 58-62.

M.S. Abdulrahman, S. Thangaraj, S.M. Salique, K.F. Khan, S.E. Natheer, Antimicrobial and biochemical analysis of some spices extracts against food spoilage pathogen, Journal of Food Safety, 2010, 12, 71-75.

R.N. Gupta, V. Kartik, P. Manoj, P.S. Singh, G. Alka, Antibacterial activities of ethanolic extracts of plants used in flok medicine, Int. Journal Res. Ayurveda Pharm., 2010, 2, 529–535.

M.K. Qader, N.S. Khalid, A.M. Abdullah, Antibacterial activity of some plant extracts against clinical pathogens, Int. Journal Microbiol. Immunol. Res., 2013, 5, 53–56.

J.J. Rios, M.C. Recio, Medicinal plants and antimicrobial activity, Journal Ethnopharmacol., 2013, 4, 92–100.

S. Saeed, P. Tariq, In vitro Antibacterial activity of clove against Gram-negative bacteria, Journal Bot., 2008, 5, 2157–2160.

R. Sapkota, R. Dasgupta, D.S. Nancy, D.S. Rawat, Antibacterial effects of plants eplants on human microbial pathogens & microbial limit tests, Int. Journal Res Pharm. Chem., 2012, 926-936.

S.B. Mishra, V.K.M. Rao, S.K. Bose, Quantitative estimation of carbohydrates by paper partition chromatography, Journal of Scientific and Industrial Research, 1960, 173-176.

S.P. Putri, M.M.M. Ikram, A. Sato, H.A. Dahlan, D. Rahmawati, Y. Ohto, E. Fukusaki, Application of gas chromatography-mass spectrometry-based metabolomics in food science and technology, Journal of Bioscience and Bioengineering, 2022, 425-435.

M. Tilyboy, G. Khaydarov, F. Saitkulov, Chromatography-Mass spectrometry and its Analytical capabilities, Development, and innovations in sciences, 2023, 2,118-121.

N. Elangovan, K.P. Sowrirajan, A.K. Madhan, Synthesis, structural investigation, computational study, antimicrobial activity and molecular docking studies of novel synthesized (E)-4- ((pyridine-4-ylmethylene) amino)-N -(pyrimidin-2-yl) benzene sulfonamide from pyridine-4-carboxaldehyde and sulfadiazine, Journal of Molecular Structure, 2021, 130544.

N. Elangovan, R. Thomas, S. Sowrirajan, Synthesis of Schiff base (E)-4-((2-hydroxy-3, 5-diiodobenzylidene) amino)-N-thiazole-2-yl) benzene sulfonamide with antimicrobial potential, structural features, experimental biological screening, and quantum mechanical studies, Journal of Molecular Structure, 2022, 131762.

N. Elangovan, G. Bhavya, R. Thomas, I. Ahmad, Synthesis of a versatile Schiff base 4-((2-hydroxy-3, 5-diiodobenzylidene) amino) benzene sulfonamide from 3, 5-diiodosalicylaldehyde and sulfanilamide, structure, electronic properties, biological activity prediction, and experimental antimicrobial properties, Journal of Molecular Structure, 2022, 131700

S. Manivel, B.S. Gangadharappa, N. Elangovan, R. Thomas, O.A. Abu Ali, I. Saleh, Schiff base (Z)-4-((furan-2-ylmethylene) amino) benzene sulfonamide: synthesis, solvent interactions through a hydrogen bond, structural and spectral properties, quantum chemical modeling and biological studies, Journal of Molecular Liquids, 2022, 118531.




DOI: http://dx.doi.org/10.13171/mjc02303201671singh

Refbacks

  • There are currently no refbacks.


Copyright (c) 2023 Mediterranean Journal of Chemistry