Cover Image

A New Cycloheptapeptide from Zanthoxylum mezoneurispinosum Aké Assi (Rutaceae)

Philomène A. Yao-Kouassi, Catherine Caron, Emma Aké-Assi, Agathe Martinez, Elisabeth Le Magrex-Debar, Sophie C. Gangloff, Monique Zèches-Hanrot

Abstract


A new cycloheptapeptide named akeassimezorine 1 and twelve known compounds: methoxy-chelerythrine 2, chelerythrine 3, nitidine 4, methoxyfagaridine 5, jatrorrhizine 6, tembetarine 7, N-methylatanine 8, magnoflorine 9, skimmianine 10, sesamine 11, hesperidine 12, and lupeol 13 were isolated from the roots of Zanthoxylum mezoneurispinosum Aké Assi (Rutaceae). The structures of those compounds were elucidated on the basis of one- and two-dimensional NMR and HR-ESI-MS analyses. Antibacterial activity of compound 1 was evaluated against pathogenic agents. This study constituted the first phytochemical investigation of the roots of Zanthoxylum mezoneurispinosum.


Full Text:

PDF

References


- D. J. Mabberly; The plant book: a portable dictionary of the higher plant. Cambridge University Press, 1987, 707.

- M. J. Cheng, I. L. Tsai and I. S. Chen, J. Chin. Chem. Soc., 2003, 50, 1241-1246.

- E. J. Adjanohoun, Contribution aux études ethnobotaniques et floristiques au Togo, Paris, France, A.C.C.T, 1986, 671.

- I. Elekwa, M. O. Monanu and E. O. Anosike, Biokemistri, 2005, 17, 7-12.

- O. M. Adegbolagun and O. O. Olukemi, Afr. J. Pharm. Pharmaco, 2010, 4, 145-150.

- O. J. Patiño, J. A. Prieto, J. M. Lozano, L. Lesmes and L. E. Cuca, Rev. Cubana Fram. 2011, 45, 431-438.

- N. Verma and R. L. Khosa, IJBB, 2010, 47, 124-127.

- J. Arrieta, B. Reyes, F. Calzada, R. Cedillo-Rivera and A. Navarrete, Fitoterapia, 2001, 72, 295-297.

- P. A. Olounlade, E. V. Azando, M. S. Hounzangbe-Adote, T. B. Ha, E. Leroy, C. Moulis, N. Fabre, J. F. Magnaval, H. Hoste and A. Valentin, Parasitol. Res., 2012, 110, 1427-1433.

- J. J. Chen, Y. H. Lin, S. H. Day, T. L. Hwang and I. S. Chen, Food Chem., 2011, 125, 282-287.

- F. Hiroyuki, K. Marii, M. Y. Kanami, S. Setsuko, S. Motoyoshi, I. Tsutomu, K. Fumiyuki and K. Nobuo, Chem. Pharm. Bull., 2010, 8, 1047-1050.

- F. Batool, S. S. Mubashir, J. B. T. Rocha, A. S. Hussain, Z. S. Saied and S. A. Dilnawad, PJB, 2010, 42, 4299-4311.

- L. Xia, J. You, G. Li, Z. Sun and Y. Suo, J. Am. Oil Chem. Soc., 2011, 88, 1029-1036.

- L. T. Tan, Phytochemistry, 2007, 68, 954-979.

- K. Tidgewell, N. Engene, T. Byrum, J. Media, T. Doi, F. A. Valeriote and W. H. Gerwick, Chem. Bio. Chem., 2010, 11, 1458-1466.

- A. Wélé, Y. Zhang, C. Caux, J. P. Brouard, L. Dubost, C. Guette, J. L. Pousset, M. Badiane and B. Bodo, J. Chem. Soc. Perkin Trans I, 2002, 2712-2718.

- A. Wélé, Y. Zhang, I. Ndoye, J. P. Brouard, J. L. Pousset and B. Bodo, J. Nat. Prod., 2004, 67, 1577-1579.

- A. N. T. Ribeiro, R. L. Da Silva, T. de S. P. Junior, N. R. Castro and G. M. A. De Carvalho, Helv. Chim. Acta, 2012, 95, 935-939.

- M. F. Talontsi, P. Facey, K. M. D. Tatong, T. M. Islam, H. Frauendorf, S. Draeger, A. Von Tiedemann and H. Laatsch, Phytochemistry, 2012, 83, 87-94.

- P. Marfey, Carlsberg Res. Commun., 1984, 49, 591-596.

- M. Grare, M. Mourer, J. B. Regnouf-de-Vains, C. Finance and R. E. Duval, Pathol. Biol., 2006, 54, 470-476.

- A. P. Yao-Kouassi, A. A. Magid, B. Richard, A. Martinez, M. J. Jacquier, C. Caron, D. E. Le Magrex, C. S. Gangloff, C. A. Ahiboand M. Zèches-Hanrot, J. Nat. Prod., 2008, 71, 2073-2076.

- N. Keawpradub, S. Dej-Adisaiand S. Yuenyongsawad,Songklanakarin J. Sci. Technol., 2005, 27 (Suppl.2), 455-467.

- H. Mozammel, B. Sufia, S. Hossain, A. Monira, M. H. Choudhury, A. Nuruddin and H. Rashedul, Pharmacogn. Mag., 2013, 9, 76-80.

- J. A Swinehart and F. R. Stermitz, Phytochemistry, 1980, 19, 1219-1223.

- J. M. Barbosa-Filho, E. V. L. Da-Cunha, M. L. Cornélio, C. D. Da Silva and A. I. Gray, Phytochemistry, 1997, 44, 959-961.

- E. Hisatomi, M. Matsui, A. Kobayashi and K. Kubota, J. Agric. Food Chem., 2000, 48, 4924-4928.

- A. P. Yao-Kouassi, A. Martinez, D. F. Malan, D. E. Le Magrex, C. S. Gangloff, C. Caron, C. A. Ahibo and M. Zèches-Hanrot, Int. J. Biol. Chem. Sci., 2014, 8, 377-385.

- D. E. Dorman and F. A. Bovey, J. Org. Chem., 1973, 38, 2379-2383.

- K. Wüthrich, M. Billeter and W. Braun, J. Mol. Biol., 1984, 180, 715-740.

- N. H. Tan and J. Zhou, Chem. Rev., 2006, 106, 840-895.




DOI: http://dx.doi.org/10.13171/mjc.3.5.2014.10.10.16.08

Refbacks

  • There are currently no refbacks.


Copyright (c) 2015 Mediterranean Journal of Chemistry