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Synthesis and Molecular modeling of some new chalcones derived from coumarine as CDC25 phosphatases inhibitors

Delel Dridi, Ahmed Bakr Abdelwahab, Emilie Bana, Patrick Chaimbault, Faouzi Meganem, Gilbert Kirsch

Abstract


New chalcones derived from coumarines were synthesized and tested as CDC25 phosphatase inhibitors. Molecular modeling of these new compounds was also presented in aim to study the mode of compounds orientation within CDC25 A and B. The reversibility of compounds 3, 4 and 5 was confirmed by application of MALDI–TOFMS technique.


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