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Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates

Juliana Alves dos Santos, Roberta C. N. Reis Corrales, Fernando R. Pavan, Clarice Queico. F. Leite, Rafael Mafra de Paula Dias, Adilson David da Silva


We reported in this work the preparation of novel 1,4-disubstituted-1,2,3-triazoles derivatives from D-glucose and D-fructose and their in vitro antibacterial activity against Mycobacterium tuberculosis were evaluated. The chemical synthesis was performed based on the 1,3-dipolar cycloaddition reaction, and antimicrobial activity was determined based on Resazurin Microtiter Assay against Mycobacterium. None of the triazole glycoconjugates tested showed activity against these microorganisms.

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