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First Description of a Guanidine-embedded Pillar[5]arene: Opening New Avenues for Biological Applications

Li Xi, Rafik Rajjak Shaikh, Priya Roosevelt, Xusheng Du, Hongliang Yu, Dylan Novack, Kamel Meguellati

Abstract


Guanidine functionality embedded in macrocyclic framework provides intriguing and tunable chemical and physical characteristics to molecular structures. We describe in this paper the first example of guanidine-containing pillar[5]arene and their potential applications in biology and material science. The reaction of O-alkylated p-aminopillar[5]arene with guanylating reagent, amidinopyrazole hydrochloride, gives first ever synthesis of a new generation of guanidine-embedded pillararene 2 under mild reaction conditions.

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DOI: http://dx.doi.org/10.13171/mjc62/01701171722-meguellati

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