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Highly diastereoselective synthesis of N-substituted 4-(diethoxyphosphoryl)-pyrrolidines-3-carboxylate starting from tetraethyl methylenediphosphonate

Maha Ameur, Aicha Arfaoui, Jihene Ben Kraiem, Salem S. Al-Deyab, Hassen Amri

Abstract


 This paper describes a convenient synthesis of novel series of 3,4-disubstituted pyrrolidines based on the aza-Michael addition of primary amines to 3,4-difunctionalized-1,3-diene followed by an intramolecular cyclization.


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DOI: http://dx.doi.org/10.13171/mjc.2.1.2012.29.07.16

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