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Relative cytotoxicity of complexes of platinum(II) and palladium(II) against pure cell culture Paramecium caudatum and human cell lines A431 and HaCaT

Aleksei Vladimirovich Eremin, Roman Vladimirovich Suezov, Polina Sergeevna Grishina, Alexander Ivanovich Ponyaev, Nicolay Leonidovich Medvedskiy


The results of cytotoxicity cis-diamine mono- and binuclear complexes of platinum(II) and palladium(II) are presented. The cytotoxicity was investigated by the method of biotesting with Paramecium caudatum and by MTT-assay with human cells: epidermoid carcinoma A431 and minimal transformed aneuploid keratinocytes HaCaT. Cytotoxicity of complexes towards protists is higher than against human cells, however, comparatively, HaCaT is more sensitive than A431 by the treatment all complexes. It is noted that cytotoxicity of palladium(II) complexes is higher than the analogues with platinum(II).

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