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Relative cytotoxicity of complexes of platinum(II) and palladium(II) against pure cell culture Paramecium caudatum and human cell lines A431 and HaCaT

Aleksei Vladimirovich Eremin, Roman Vladimirovich Suezov, Polina Sergeevna Grishina, Alexander Ivanovich Ponyaev, Nicolay Leonidovich Medvedskiy


The results of cytotoxicity cisplatin-like complexes of platinum(II) and palladium(II) are presented. The cytotoxicity was researched by method of  biotesting with Paramecium caudatum and by MTT-assay with human cells: epidermoid carcimoma A431 and minimal transformed aneuploid keratinocytes HaCaT. Cytotoxicity of complexes toward protists is high, however, comparatively HaCaT are more sensitive than A431. Furthemore, cytotoxicity of palladium(II) complexes is higher than the analogues with platinum(II).

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