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Selective Release of anti–TB Drugs Complex from Smart Copolymeric Bioactive nano–carriers

Alejandro Arredondo–Penaranda, Luis Guillermo Guerrero–Ramirez, Maria Dolores Blanco Gaitan, Eduardo Mendizabal, Issa Katime


Smart nano–copolymeric matrices have been employed to load and release anti tuberculosis (anti –TB) drugs combinated complexes of Ethambutol (EMB), Isoniazid (INH), Rifampicin (RMP) and Pyrazinamide (PZA). Copolymeric nanocarriers were synthesized using a microemulsion polymerization method previously reported. These nanocarriers can show selective swelling–collapse response under changes in local environments such a temperature, pH, solvent composition and electrical stimuli. The employ of these kinds of systems permits a controlled and selective delivery and release on specific human tissues. High Performance Liquid Chromatography technique was used to allow the detection of combinated mixtures of different active principles of anti–TB drugs using an acetonitrile mobile phase at 0.5 mL/min of flow rate whit a Spherisorb ODS2, C18 column. The results obtained suggest that the employ of smart nanohydrogels is a novel method in several tuberculosis therapies.

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