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Diastereoselective Synthesis of some pyrrolidin-2-ones azasugars and study of their stereochemistry

Chahrazed Benhaoua, Mustapha Rahmouni, Hadj Benhaoua


The microwave-promoted one-pot multicomponent synthesis of substituted pyrrolidinols using a bifunctional sugar-derived hydroxy-[gamma]-lactone component of amine component or cyanide group is reported. Clean reaction profile, easy work-up procedure, excellent yields and short reaction times are some remarkable features of this method.

This modular approach features the in situ-generation of iminium ions intermediate that allows the diastereoselective assembly of the diverse pyrrolidinones efficiently under microwave irradiation has been used.

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