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An expedient approach for the synthesis and the anti-acetylcholinesterase activity evaluation of 6H-benzimidazol[1,2-c][1,3,2]benzoxazaphosphorine 2-(4-methoxyphenyl)-2-sulfide derivatives from 4-mercapto-2H-chromene-2-thione

Imen Zghab, Belsem Trimeche, Anis Romdhane, David Touboul, Hichem Ben Jannet

Abstract


A new efficient route for the synthesis of substituted 6H-benzimidazol[1,2-c][1,3,2] benzoxazaphosphorine 2-(4-methoxyphenyl)-2-sulfide from 4-mercapto-2H-chromene-2-thione is described. The anti-acetylcholinesterase activity of the most important synthons is considered. Ways of constructing six-membered phosphorus-heterocycles via cyclization of Lawesson’s reagent with bifunctional substrates are discussed.

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DOI: http://dx.doi.org/10.13171/mjc.1.3.2011.03.12.23

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