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Characterization of curcumin-nicotine interaction in cetyltrimethyammonium bromide micelle

Maurice O. Iwunze

Abstract


A combination of fluorescence and UV-Vis spectrophotometric techniques were used to characterize the interaction of curcumin and nicotine in a cetyltrimethylammonium bromide (CTAB) micellar system. It is observed that in this medium curcumin and nicotine interact in a 1:1 ratio using the UV-Visible molar ration method. The fluorescence spectrophotometric technique, using the Benesi-Hildebrand equation was used to determine the association constant, Ka. The value thus obtained is 1.26 ± 0.02 x 105 M-1 and the molar absorptivity, ε, of 2.3 ±0.06 x 104/M-cm. The free energy of association, △Ga, was subsequently calculated as -29.1 kJ/mol. This vale together with the value obtained for Ka implies that the complex formed by curcumin and nicotine in this medium is not only spontaneous but it also very stable.

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DOI: http://dx.doi.org/10.13171/mjc.3.1.2014.12.04.16

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