Cover Image

Characterization of curcumin-nicotine interaction in cetyltrimethyammonium bromide micelle

Maurice O. Iwunze

Abstract


A combination of fluorescence and UV-Vis spectrophotometric techniques were used to characterize the interaction of curcumin and nicotine in a cetyltrimethylammonium bromide (CTAB) micellar system. It is observed that in this medium curcumin and nicotine interact in a 1:1 ratio using the UV-Visible molar ration method. The fluorescence spectrophotometric technique, using the Benesi-Hildebrand equation was used to determine the association constant, Ka. The value thus obtained is 1.26 ± 0.02 x 105 M-1 and the molar absorptivity, ε, of 2.3 ±0.06 x 104/M-cm. The free energy of association, △Ga, was subsequently calculated as -29.1 kJ/mol. This vale together with the value obtained for Ka implies that the complex formed by curcumin and nicotine in this medium is not only spontaneous but it also very stable.

Full Text:

PDF

References


- ChemistryDaily.com 2005.

- http:/www. Woldofmolecules.com/drugs/nicotine.htm.

- M.L. Solt, Plant physiol, 1957, 32, 480-484.

- M.L. Solt, Ibid, 1957, 32, 484-490.

- R.C. Jiloha, Indian. J. Psychiatry, 2010, 54(4), 301-307

- R. Schwartz-Bloom, G.G. de Nunez, www.Pbs.org/wgbh/nova/cigarette/nicotine_nfp.htm.

- S. Banerjee, G. Bandyopudhyaya, K. Chattopadhyay, B.D. Chattopadhyay, In. J. Pharmacol., 2010, 6(4), 444-455.

- J.A. Dani, D. Ji, F.M. Zhou, Synaptic Plasticity and Nicotine Addiction, Neuron, 2001, 31, 349-352.

- D.J. K. Balfour, A.E. Wright, M.E.M. Benwell, C.E. Birrell, Behavioural Brain Research, 2000, 113, 73-83.

- Y. Wang, H.F. Sun, H.F. Wang, Y.F. Liu, Chinese Chemical Letters, 2001, 12(5), 449-452.

- M.N. Tiwani, S. Agarwall, P. Bhatimagan, N.K. Singhall, S.K. Tiwani, P. Kumar, L. Kumar, S. Chaulham,, D.K. Patel, R.K. Chaturwedii, M.P. Singh, K.C. Gupta, Free Radical Biology and Medicine, 2008, 65, 704-718.

- L.T. Sorensen, B.G. Toft, J. Rygaard, S. Ladelund, M. Paddon, T.James, R. Taylor, F. Gottrup, Surgery, 2010, 148(5), 982-990.

- S.K. Mahapatra, S. Das, S. Bhattaacjarjee, N. Gautam, S. Majumdar, S. Roy, Toxicology Mechanisms and Methods, 2009, 19(2), 100-108.

- K. Chattopudhyay, B.D. Chattopudhyay, Indian J. Med. Res., 2008, 127, 571-576.

- M.B. Newman, G.W. Arendash, R.D. Shytle, P.C. Bickford,T. Tioghe, P.R. Sanberg, Life Sciences, 2002, 71, 2807-2820.

- A. Nordberg, E.H. Lindahl, M. Lee, M. Johnson, M. Mousavi, R. Hall, E. Perry, I Bednar, J. Court, J. Neurochem., 2002, 81, 655-658.

- Y. P. Wu, K. Kita, N. Suzuki, In. J. Cancer, 2002, 100, 37-42.

- D. Yildiz, N. Ercal, D.W. Armstrong, Toxicology, 1998, 130, 155-165.

-D.J. Socci, P.R. Sanberg, G.W. Arendash, Neurobiolgy of Aging, 1995, 16(5), 857-860.

- R.D. Shytle, C.V. Borlongan, P.R. Sanberg, Neuropsychopharmacology, 1995, 13(3), 261-264.

- J. Barron, Baseline of Health Foundation, 2010

- C. Kalpana, A.R. Sudheer, K.N. Rajasekharan, V.P. Menon, Singapore Med., 2007, 48(2), 124-130.

- C. Kalpana, V.P. Menon, Pol. J. Pharmacol. 2004, 56, 581-586.

- G.Bandyopadyaya, S. Sinha, B.D. Chattopadhyay, A. Chakraborty, European J. Phrmacol, 2008, 588, 151-157.

- S. Sinha, M. Maiti, K. Chattopadhyay B. Chattopadyay, J. Pharmacol. Toxicol., 2012, 7(4), 166-180.

- X.Z. Cheng, X.S. Yang, L.W. Zhang, Z. Xi, J. Songhai Jiaotong University (Agricul. Science), 2006, 1, 44-47.

- Y. Wang, Y. Cheng, H.F. Sun, Chinese Chem. Letters, 2000, 11(3), 247-250.

- H.A. Benessi, J.H. Hildebrand, J. Am. Chem. So., 1949, 17, 2703-2707.

- M. Riri, O. Kamal, A. Benjjar, F. Serdaoui, M. Hlaibi, Open J. Phys. Chem. 2013, 3, 49-58.




DOI: http://dx.doi.org/10.13171/mjc.3.1.2014.12.04.16

Copyright (c) 2015 Mediterranean Journal of Chemistry