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Synthesis and antitubercular evaluation of aryl substituted 2-oxazolines from L-amino acids

Leidiane Araujo de Souza, Emerson Teixeira da Silva, Maria Cristina Silva Lourenço, Marcus Vini­cius Nora de Souza

Abstract


This paper describes the synthesis and the in vitro antibacterial activity of a series of twelve substituted aryl-2-oxazolines against Mycobacterium tuberculosis. Seven compounds showed activity and two compounds exhibited a minimal inhibitory concentration (MIC) of 25 ï­g/mL were not cytotoxic for the host cells in cell viability assay. These results could be a good starting point for the development of new antitubercular lead series based on this family of compounds.

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DOI: http://dx.doi.org/10.13171/mjc.2.5.2014.06.01.23

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