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Novel Schiff base ligand and its Co(II) & Cu(II) Metal complexes: Synthesis, Physicochemical Characterization, DNA Binding, and Antifungal Screening

Anshita Varshney, Deepshikha Gupta, Ankit Kumar Choubey, Shivanshu Brahmchari, A. P. Mishra


A novel Schiff base ligand 4-chloro-2-(2,5-dimethoxybenzylideneamino)-5-nitrophenol derived from 2,5-dimethoxybenzaldehyde and 2-amino-4-chloro-5-nitrophenol. Its Co(II) and Cu(II) transition metal chelates were also synthesized and physicochemically characterized by FT-IR, UV-Vis absorption spectroscopy, Thermogravimetric analysis (TGA), and Electrochemical studies. These compounds are biologically active and exhibit antifungal and DNA-binding activity. The Cu(II) metal complex gives better biological activity than the Co(II) metal complex and parent Schiff base ligand. 

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