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Synthesis, Characterization, Aggregation behaviors, Antioxidant and Anti-inflammatory activities of Unmetalled and metallophthalocyanines bearing 2(3,4-dimethoxyphenyl)ethanol and 4-Hydroxybenzaldehyde groups

Abduallah Sulaiman

Abstract


Novel metallophthalocyanines (M: Co, Cu, Ni) containing 2(2-methoxyphenyl)ethanol and 3-Hydroxybenzaldehyde groups  were synthesized and characterized.

The structures were confirmed by IR, UV/vis, 1H NMR, 13C NMR, mass spectroscopy  and elemental analysis. The aggregation behavior of these compounds was investigated in DMSO.  In addition; the compounds 4-9 were investigated for anti-oxidant activities by super oxide radical; DPPH (2,2-Diphenyl-1-picrylhydrazyl); and hydroxyl radical scavenging assays; in which most of them  displayed significant antioxidant activities. Furthermore; compounds 4-9   were evaluated for anti-inflammatory activity by indirect hemolytic and lipoxygenase inhibition assays and revealed good activity.


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DOI: http://dx.doi.org/10.13171/mjc56/01607261513/alayed

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