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Synthesis, structural characterization and DNA studies of trivalent cobalt complexes of (2E)-4N-substituted-2-[4-(propan-2-yl)benzylidene]hydrazinecarbothioamide

Murali Krishna Panchangam, Hussain Reddy K


This paper describes trivalent cobalt complexes of hydrazinecarbothioamides derived from 4-(propan-2-yl) benzaldehyde and substituted thiosemicarbazides NH2NHC(S)NHR, where R = H (1), Me (2), Et (3) or Ph (4) have been synthesized and characterized. The prepared ligands and complexes were characterized using various physicochemical techniques viz. elemental analysis, molar conductance, magnetic susceptibility measurements, IR, electronic absorption spectral studies and cyclic voltammetry. The electronic spectra in DMSO solvent and magnetic susceptibility data of complexes reveal that the complexes are diamagnetic with low spin octahedral cobalt(III) complexes. The absorption titration studies revealed that each of these complexes is an avid binder to calf thymus-DNA. The apparent binding constants are in the order of 107–108 M-1 . The nucleolytic cleavage activities of the ligands and their complexes were assayed on pUC18 plasmid DNA using gel electrophoresis in the presence and absence of H2O2. The ligands showed increased nuclease activity when administered as cobalt complexes. All the complexes behave as efficient chemical nucleases with hydrogen peroxide activation. These studies revealed that the complexes exhibit both oxidative and hydrolytic chemistry in DNA cleavage.

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Elemike E.E., Oviawe A.P., Otuokere I.E., Res.J. chem. Sci., 2011, 1(8), 6.

Opletalová V, Kalinowski DS, Vejsová M, et al., Chem Res Toxicol 2008, 21, 1878.

Buschini A, Pinelli S, Pellacani C, et al., J Inorg Biochem., 2009, 103, 666.

Kovala-Demertzi D, Papageorgiou A, Papathanasis L, et al, Eur J Med. Chem 2009; 44: 1296.

Dehdashti F, Grigsby PW, Lewis JS, Laforest R, Siegel BA, Welch M J, J Nucl Med 2008, 49, 201.

P. Murali Krishna, Hussain Reddy K, Pandey J P, Dayananda Siddavattam, Transition Met. Chem., 2008, 33(5), 661.

P. Murali Krishna, Hussain Reddy K, Inorganica Chimica Acta 2009, 362, 4185.

D. Pandiarajan, R. Ramesh, Inorg. Chem. Commun., 2011, 14, 686.

- N. SahaChowdhury, D. Kumar Seth, M.G.B. Drew, S. Bhattacharya, Inorg. Chim.Acta., 2011, 372, 183.

Patel N.Cand Bhavesh A. Patel, Research Journal of Chemical Sciences, 2014, 4(2), 1.

Tetsumi T., Sumi M., Taraka M. and Shono T., Polyhedron, 1986, 5(3), 707.

Buttrus N.H. and Mohamed S.M., Res. J. Chem. Sci., 2013, 3(6), 54.

N.B. Gopal Reddy, P. Murali Krishna, Nagaraju Kottam, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2015, 137, 371.

P. Murali Krishna, N. B. Gopal Reddy, Dr. Nagaraja K, and Yallur B. C, The Scientific World Journal, Volume 2013, Article ID 828313, 7 pages

G. Pelosi, The Open Crystallography Journal, 2010, 3(2), 16.

. Franco Bisceglie, Silvana Pinelli, Rossella Alinovi, Matteo Goldoni, Antonio Mutti, Alessandro Camerini, Lorenzo Piola, Pieralberto Tarasconi, Giorgio Pelosi, J. Inorg Biochem., 2014, 140, 111.

. Quiroga AG, Perez JM, Montero EI, West DX, Alonso C, Navarro-Ranninger C, J Inorg. Biochem., 1999, 75(4), 293.

. Perez JM, Matesanz AI, Martin-Ambite A, Navarro P, Alonso C, Souza P, J Inorg Biochem., 1999, 75, 255.

. P. Murali Krishna, K. Hussain Reddy, J. P. Pandey, Dayananda Siddavattam, Transition Met. Chem., 2008, 33(5), 661.

. P. Murali Krishna, Katreddi Hussain Reddy, Inorg. Chim. Acta, 2009, 362, 4185.

P Murali Krishna and K Hussain Reddy, Journal of Chemical and Pharmaceutical Research, 2016, 8(10), 61.

N.B. Gopal Reddy, P. Murali Krishna, S.S. Shantha Kumar, Yogesh P. Patil, Munirathinam Nethaji, Journal of Molecular Structure (In Press, 2017)

B. S. Shankar, N. Shashidhar, Yogesh Prakash Patil, P. Murali Krishna and Munirathinam Nethaji, Acta Cryst. 2013. E69, o61

P. Murali Krishna, B. S. Shankara, N.Shashidhar, International Journal of Inorganic Chemistry, vol. 2013, Article ID 741269, 11 pages, 2013. (doi:10.1155/2013/741269)

P. Murali Krishna, K. Hussain Reddy, Der Pharma Chemica, 2013, 5 (5), 258.

P. Murali Krishna, G. N. Anil Kumar, Hussain Reddy K and M. K. Kokila, Acta Cryst. 2012. E68, o2842.

P. Murali Krishna, Hussain Reddy K, Pitchika G Krishna & G H Philip, Ind. J. Chem., 2007, 46A, 904.

. Marmur J, J Mol Biol., 1961, 3, 208.

. Reichmann ME, Rice SA, Thomas CA, Doty P, J. Am. Chem. Soc., 1954, 76(11), 3047.

. Wolfe A, Chimer GH, Meechan T, Biochemistry, 1987, 26(20), 6392.

W. J. Geary, Coord. Chem. Rev., 1971, 7, 81.

J. S. Casas, A. Sanchez, J. Sorda, A. Vazquez-Lopez, E. E. Castellano, J. kermann- Schechter, M. C. Rodriguez-Arguelles, U. Russo, Inorg. Chim. Acta, 1994, 16,169.

. J. S. Casas, A. Castineirras, A. Sanchez, J. Sorda, A. Vazquez-Lopez, M. C Rodriguez-Arguelles, U. Russo, Inorg. Chim. Acta, 1994, 221, 61.

. M. J. M. Campbell, Coord. Chem. Rev., 1975, 15, 279.

. D. X. West, A. E. Liberta, S. B. Padhye, R. C. Chikte, P. B. Sonawane, A.S. Kumbhar, R. G. Yerande, Coord. Chem. Rev., 1993, 123,49.

. C.V.Sastri, D. Eswaramoorthy, L.Giribabu, B.G.Maiya., J.Inorg. Biochem. 2003, 94, 138.



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