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Bioactive flavonoid from the Commelina obliqua Vahl. and its In vitro anti-inflammatory activity

Kesar Singh, R N Yadava, Ritu Yadav

Abstract


Commelina obliqua Vahl. This plant is a member of the Commelinaceae family, commonly referred to as the dayflower family. An entirely new bioactive compound recently discovered and identified 3, 5, 7, 3' 4′-pentahydroxy flavone-7-O-L-ribopyranosyl-3′-O-D-galactopyranoside having a melting point 320-22°C, molecular formula C26H28O16, m/z [595-H]- ESI-MS negative mode by different chemical color reactions, chemical decomposition, and spectral analysis 1HNMR, 13CNMR, Electron spray ionization mass spectrometry, Fourier transform infrared spectroscopy. An in vitro anti-inflammatory test revealed significant anti-inflammatory effects besides the degradation of egg albumin. Compound M illustrated the more percentage inhibitory action (123.1974%) of protein denaturation at 500 μg/ml, and Diclofenac sodium demonstrated less inhibitory activity (120.0627%) at the equivalent combination. As a result, Compound M inhibits protein denaturation more effectively than Diclofenac sodium at the same combination. Therefore, compound M may utilize as an anti-inflammatory source.

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References


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DOI: http://dx.doi.org/10.13171/mjc03303021681singh

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