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Elimination of gatifloxacin from water: Treatment by electro-Fenton process and highlighting of a biological post-treatment

Mohamed Reda Arhoutane, Ghizlan Kaichouh, Muna Shueai Yahya, Miloud El Karbane, Hind Chakchak, Kacem El Kacemi

Abstract


This study concerns the oxidative degradation and mineralization of gatifloxacin in aqueous solution at pH = 3 and in the presence of Fe2+ as catalyst  using electro-Fenton (EF) process, with carbon felt as a cathode and platinum as an anode. The mineralization is evaluated by the chemical oxygen demand by assessing the applied current value and concentration of catalyst Fe2+. Some stable by-products of gatifloxacin have been identified using high-performance liquid chromatography and liquid chromatography tandem mass spectrometry. The second part of this paper concerns the study of the biodegradability in determining of BOD5/COD during the mineralization of gatifloxacin by EF in order to evaluate the possibility of coupling electro-Fenton process with the biological one. This leads to an efficient treatment of water contaminated by this antibiotic with lower cost.


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References


- a) F. Weber, T. Beek, A. Bergmann, A. Carius, G. Grüttner, S. Hickmann, Les Produits Pharmaceutiques dans l'Environnement Perspective à l'Echelle Mondiale. Présence, Effets, et Action Concertée Potentielle au Titre de la SAICM, 2014.

b) D. Destrieux, F. Laurent, H. Budzinski, J. Pedelucq, P. Vervier, M. Gerino, Drug residues in urban water: A database for ecotoxicological risk management, Science of the Total Environment, 2017, 609, 927-941.

- U. Von Gunten, Ozonation of Drinking Water: Part I, Oxidation Kinetics and Product. Formation. Water Res., 2003, 37, 1443-1467.

- A. Fujishima, X. Zhang, D. A. Tryk, Photocatalysis and Related Surface Phenomena. Surf. Science Rep, 2008, 63, 515-582.

- A. Y. C. Tong, B. Braund, D. S. Warren, B. M. Peake, TiO2-assisted Photodegradation of Pharmaceuticals, a review. Cent. Eur. J. Chem., 2012, 10, 989-1027.

- M. A. Oturan, An Ecologically Effective Water Treatment Technique Using Electrochemically Generated Hydroxyl Radicals for in Situ Destruction of Organic Pollutants. Application to Herbicide 2,4-D. Appl Electrochem, 2000, 30, 477-48

- M. Sh. Yahya, N. Oturan, K. El Kacemi, M. El Karbane, C. T. Aravindakumar, M. A. Oturan, Oxidative Degradation Study on Antimicrobial Agent Ciprofloxacin by Electro-Fenton Process: Kinetics and Oxidation Products. Chemosphere, 2014, 117, 447-454.

- M. Sh. Yahya, M. El Karbane, N. Oturan, K. El Kacemi, M. A. Oturan, Mineralization of the Antibiotic Levofloxacin in Aqueous Medium by Electro- Fenton Process: Kinetics and Intermediate Products Analysis. Environ Technol, 2016, vol. 37, NO. 10, 1276-1287.

- M. Sh. Yahya, N. Beqqal, A. Guessous, M. R. Arhoutane, K. El Kacemi, Degradation and Mineralization of Moxifloxacin Antibiotic in Aqueous Medium by Electro-Fenton Process: Kinetic Assessment and Oxidation Products. Cogent Chemistry, 2017, 3, 1290021.

- M. A. Oturan, I. Sirès, N. Oturan, S. Pérocheau, J. L. Laborde, Sonoelectro Fenton Process: A Novel Hybrid Technique for the Destruction of Organic Pollutants in Water. J. Electroanal. Chem., 2008, 624, 329-332.

- L. Ge, C. Halsall, C. Chen, P. Zhang, Q. Dong, Z. Yao, Exploring the Aquatic Photodegradation of Two Ionisable Fluoroquinolone Antibiotics Gatifloxacin and Balofloxacin: Degradation Kinetics, Photo byproducts and Risk to the Aquatic Environment, Sci. Total Environ., 2018, 633, 1192-1197

- G. Linke, C. JingWen*, Z. SiYu, C. XiYun, W. Zhuang, W. ChunLing, Photodegradation of Fluoroquinolone Antibiotic Gatifloxacin in Aqueous Solutions, Environ. Chem., 2010, Vol.55 No.15: 1495-1500

- A. Wang, J. H. Qu, J. Ru, Mineralization of an Azo Dye Acid Red 14 by Electro-Fenton`s Reagent Using an Activated Carbon Fiber Cathode. Dyes Pigments, 2005, 6, 227-233.

- I. Sirés, N. Oturan, M. A. Oturan, R. M. Rodríguez, J. A. Garrido, E. Brillas, Electro-Fenton Degradation of Antimicrobials Triclosan and Triclocarban. Electrochim. Acta, 2007, 52, 5493-5503.

- E. Isarain-Chávez, C. Arias, P. L. Cabot, F. Centellas, R. M. Rodríguez, J. A. Garrido, E. Brillas, Mineralization of the Drug ß-blocker Atenolol by Electro-Fenton and Photoelectro-Fenton Using an Air- diffusion Cathode for H2O2 Electrogeneration Combined with a Carbon-felt Cathode for Fe2+ Regeneration. Application Catalytic B-Environnement, 2010, 96, 361-369.

- C. M. Rui, A. F. Rossi, R. M. Quinta-Ferreira, Fenton’s Oxidation Process for Phenolic Wastewater Remediation and Biodegradability Enhancement, J. Hazard. Mater., 2010, 180, 716-721.

- S. Sonia, A. M. Polo, M. Tobajas, J. J. Rodriguez., A. F. Mohedano, Degradation of Chlorophenoxy Herbicides by Coupled Fenton and Biological Oxidation. Chemosphere, 2013, 93, 115-122.

- L. Li-An, M. Ying-Shih, M. Kumar, L. Jih-Gaw, Photo-Fenton Pretreatment of Carbofuran Analyses via Experimental Design, Detoxification and Biodegradability Enhancement. Sep. Purif. Technol., 2011, 81, 325-331.

- M. Dorsaf, F. Fourcade, I. Soutrel, D. Hauchard, N. Bellakhal, A. Amrane, Relevance of a Combined Process Coupling Electro-Fenton and Biological Treatment for the Remediation of Sulfamethazine Solution Application to an Industrial Pharmaceutical Effluent. C. R. Chimie, 2015, 18, 39-44.

- O. Hugo, T. Cocerva, N. Oturan, D. Buisson, M. A. Oturan, A Sustainable Integrated Process for Removal of Organic Pollutants from Water: Application to Mineralization of Metoprolol. J. Hazard. Mater., 2016, 319, 13-23.

- A. Cyrine, F. Fourcade, I. Soutrel, F. Geneste, D. Floner, N. Bellakhal, A. Amrane, Degradation of Enoxacin Antibiotic by the Electro-Fenton Process: Optimization, Biodegradability Improvement and Degradation Mechanism. J. Environ. Manage., 2016, 165, 96-105.

- D. Mantzavinos, E. Psillakis, Enhancement of Biodegradability of Industrial Wastewaters by Chemical Oxidation Pre-treatment. J. Chemistry. Technology. Biotechnology, 2004, 79, 431-454.

- J. J. Pignatello, Y. Sun., Complete Oxidation of Metolachlor and Methyl Parathion in Water by the Photoassisted Fenton Reaction. Water Res., 1995, 29, 837-1844.

- B. Boye, M. M. Dieng, E. Brillas, Degradation of Herbicide 4-Chlorophenoxyacetic Acid by Advanced Electrochemical Oxidation Methods. Environ. Sci. Technol., 2002, 36, 3030-3035.

- N. Oturan, M. Panizza, M. A. Oturan, Cold Incineration of Chlorophenols in Aqueous Solution by Electro- Fenton Process. Effect of Number and Position of Chlorine Atoms on the Degradation Kinetics. J. Phys. Chem., 2009, A 113, 10988-10993.

- A. Dirany, Études cinétique et mécanistique d'oxydation/minéralisation des antibiotiques sulfaméthoxazole (SMX), amoxicilline (AMX) et sulfachloropyridazine (SPC) en milieux aqueux par procédés électrochimiques d'oxydation avancée. Mesure et suivi d'évolution de la toxicité lors du traitement, 2010.

- M. Sh. Yahya, N. Oturan, K. El Kacemi, M. El Karbane, C. T. Aravindakumar, M. A. Oturan, Oxidative Degradation Study on Antimicrobial Agent Ciprofloxacin by Electro-Fenton Process: Kinetics and Oxidation Products. Chemosphere, 2014, 117, 447-454.

- E. Brillas, I. Sirés, M. A. Oturan, Electro-Fenton Process and Related Electrochemical Technologies Based on Fentonés Reaction Chemistry. Chem. Rev. 2009, 109, 6570-6631.

- H. Zazou, N. Oturan, H. Zhang, M. Hamdani, M. A. Oturan, Comparative study of electrochemical oxidation of herbicide 2,4,5-T: Kinetics, parametric optimization and mineralization pathway. Sustainable Environ. Res., 2017, 27, 15-23.

- www.pharmaffiliates.com/impurities/2023/gatifloxacin

- www.bocsci.com/im-gatifloxacin-and-impurities-list-180.html

- N. Oturan, M. Panizza, M. A. Oturan, Cold Incineration of Chlorophenols in Aqueous Solution by Electro- Fenton Process. Effect of Number and Position of Chlorine Atoms on the Degradation Kinetics. J. Phys. Chem., 2009, A 113, 10988-10993.

- J. Kondo, M. Koganei, T. Kasahara, Crystal Structure and Specific Binding Mode of Sisomicin to the Bacterial Ribosomal Decoding Site, ACS Med. Chem. Lett., 2012, 3, 741-744.

- W. Ulrich, A. Sievers-Engler, M. Lämmerhofer, Preparation of Fluorescent Labeled Gentamicin as Biological Tracer and Its Characterization by Liquid Chromatography and High-Resolution Mass Spectrometry. J Pharm Biomed Anal., 2016, 121, 307-315.

- R. Grahek, L. ZupanÄiÄ-Kralj, Identification of Gentamicin Impurities by Liquid Chromatography-Tandem Mass Spectrometry, J. Pharm. Biomed. Anal., 2009, 1037-1043.

- J. Berdy, J. Kadar Pauncz, Z. Mehesfalvi Vajna, G. Horvath, J. Gyimesi, I. Koczka, Metabolites of Gentamicin-producing Micromonospora Species 1. Isolation and Identification of Metabolites, J. Antibiot., 1977, VOL. XXX NO. 11.

- European Pharmacopoeia 8.0.




DOI: http://dx.doi.org/10.13171/mjc841906066mra

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